Drug interactions
Nintedanib + Ticagrelor
Severity: Moderate
Nintedanib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor inhibits P-glycoprotein and may increase nintedanib exposure, raising the likelihood of gastrointestinal effects and liver enzyme elevations. Nintedanib also carries a bleeding risk that overlaps with ticagrelor.
What this interaction means in plain words
Nintedanib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by ticagrelor increases nintedanib absorption.
What to do
Monitor for nintedanib adverse effects and liver tests, and for bleeding. Reduce the dose or interrupt nintedanib if not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Ticagrelor?
MediHelp rates the interaction as moderate. Nintedanib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor inhibits P-glycoprotein and may increase nintedanib exposure, raising the likelihood of gastrointestinal effects and liver enzyme elevations. Nintedanib also carries a bleeding risk that overlaps with ticagrelor.
How serious is the interaction between Nintedanib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nintedanib adverse effects and liver tests, and for bleeding. Reduce the dose or interrupt nintedanib if not tolerated.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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