Drug interactions
Nintedanib + Verapamil
Severity: Moderate
Nintedanib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and may raise nintedanib exposure, increasing the risk of gastrointestinal effects and liver enzyme elevations.
What this interaction means in plain words
Nintedanib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux of nintedanib, increasing its systemic exposure.
What to do
Monitor for nintedanib adverse effects such as diarrhea, nausea and raised transaminases. Interrupt or reduce the nintedanib dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Verapamil?
MediHelp rates the interaction as moderate. Nintedanib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-glycoprotein and may raise nintedanib exposure, increasing the risk of gastrointestinal effects and liver enzyme elevations.
How serious is the interaction between Nintedanib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nintedanib adverse effects such as diarrhea, nausea and raised transaminases. Interrupt or reduce the nintedanib dose if they occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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