Drug interactions
Nintedanib + Vinblastine
Severity: Minor
Nintedanib and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is a P-gp substrate and competitor, and no established inducing effect on P-gp exists. Any change in nintedanib levels is uncertain; the more likely concern is additive gastrointestinal and hematologic toxicity.
What this interaction means in plain words
Nintedanib and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nintedanib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Possible competition at P-gp; the mechanism is not well established and no clear reduction in nintedanib exposure is known.
What to do
No dose change is routinely needed; monitor for diarrhea, liver enzymes and blood counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Vinblastine?
MediHelp rates the interaction as minor. Nintedanib and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinblastine is a P-gp substrate and competitor, and no established inducing effect on P-gp exists. Any change in nintedanib levels is uncertain; the more likely concern is additive gastrointestinal and hematologic toxicity.
How serious is the interaction between Nintedanib and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for diarrhea, liver enzymes and blood counts.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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