Drug interactions
Nisoldipine + Sotalol
Severity: Moderate
Nisoldipine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nisoldipine lowers blood pressure through vasodilation, and sotalol adds beta-blockade, which may result in excess hypotension or bradycardia in some patients.
What this interaction means in plain words
Nisoldipine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from dihydropyridine calcium channel blockade and beta-blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug, and reduce the dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Sotalol?
MediHelp rates the interaction as moderate. Nisoldipine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nisoldipine lowers blood pressure through vasodilation, and sotalol adds beta-blockade, which may result in excess hypotension or bradycardia in some patients.
How serious is the interaction between Nisoldipine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug, and reduce the dose if symptomatic hypotension develops.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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