Drug interactions
Nisoldipine + Temsirolimus
Severity: Moderate
Nisoldipine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors have been associated with angioedema, and the risk appears higher with concomitant calcium channel blockers. Nisoldipine is also a CYP3A4 substrate, though the interaction concern is mainly angioedema.
What this interaction means in plain words
Nisoldipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
The mechanism is not well established; additive effects on bradykinin-mediated vascular permeability have been proposed.
What to do
Counsel patients to report swelling of the face, lips, tongue, or throat, and stop the offending drug if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Temsirolimus?
MediHelp rates the interaction as moderate. Nisoldipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. mTOR inhibitors have been associated with angioedema, and the risk appears higher with concomitant calcium channel blockers. Nisoldipine is also a CYP3A4 substrate, though the interaction concern is mainly angioedema.
How serious is the interaction between Nisoldipine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips, tongue, or throat, and stop the offending drug if angioedema occurs.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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