Drug interactions
Nitisinone + Zafirlukast
Severity: Moderate
Nitisinone and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is partly cleared by CYP2C9, which nitisinone inhibits. Zafirlukast exposure may increase, raising the risk of adverse effects such as headache, gastrointestinal upset and liver enzyme elevation.
What this interaction means in plain words
Nitisinone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nitisinone belongs to Miscellaneous; Zafirlukast belongs to Respiratory.
Why it happens
Nitisinone inhibits CYP2C9, reducing zafirlukast metabolism.
What to do
Monitor for zafirlukast adverse effects, including hepatic symptoms, and check liver tests if they occur. Reduce the zafirlukast dose or choose an alternative if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Nitisinone with Zafirlukast?
MediHelp rates the interaction as moderate. Nitisinone and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zafirlukast is partly cleared by CYP2C9, which nitisinone inhibits. Zafirlukast exposure may increase, raising the risk of adverse effects such as headache, gastrointestinal upset and liver enzyme elevation.
How serious is the interaction between Nitisinone and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zafirlukast adverse effects, including hepatic symptoms, and check liver tests if they occur. Reduce the zafirlukast dose or choose an alternative if toxicity develops.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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