Drug interactions
Nitrofurantoin + Vadadustat
Severity: Minor
Nitrofurantoin and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may raise exposure to BCRP substrates. Nitrofurantoin is a possible BCRP substrate, so levels might increase, with unclear clinical effect.
What this interaction means in plain words
Nitrofurantoin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitrofurantoin belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibition of intestinal BCRP efflux may increase nitrofurantoin absorption.
What to do
No routine dose change is needed. Monitor for nitrofurantoin adverse effects, especially in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Nitrofurantoin with Vadadustat?
MediHelp rates the interaction as minor. Nitrofurantoin and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits BCRP and may raise exposure to BCRP substrates. Nitrofurantoin is a possible BCRP substrate, so levels might increase, with unclear clinical effect.
How serious is the interaction between Nitrofurantoin and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for nitrofurantoin adverse effects, especially in patients with renal impairment.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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