Drug interactions
Nizatidine + Posaconazole
Severity: Moderate
Nizatidine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole oral suspension needs gastric acid for absorption, so H2 blockers can lower its levels, which risks antifungal failure. The effect is much smaller with delayed-release tablets.
What this interaction means in plain words
Nizatidine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nizatidine belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Increased gastric pH reduces dissolution and absorption of posaconazole suspension.
What to do
Use delayed-release tablets or IV posaconazole, or avoid the suspension with H2 blockers. Check posaconazole trough levels if suspension must be used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Nizatidine with Posaconazole?
MediHelp rates the interaction as moderate. Nizatidine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole oral suspension needs gastric acid for absorption, so H2 blockers can lower its levels, which risks antifungal failure. The effect is much smaller with delayed-release tablets.
How serious is the interaction between Nizatidine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use delayed-release tablets or IV posaconazole, or avoid the suspension with H2 blockers. Check posaconazole trough levels if suspension must be used.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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