Drug interactions
Norethisterone + Stiripentol
Severity: Moderate
Norethisterone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP enzymes, so norethisterone exposure may increase or decrease unpredictably. Reduced exposure could compromise contraception.
What this interaction means in plain words
Norethisterone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Norethisterone belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol.
What to do
Monitor for breakthrough bleeding or adverse effects and add non-hormonal contraception if contraception is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Norethisterone with Stiripentol?
MediHelp rates the interaction as moderate. Norethisterone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol both inhibits and induces CYP enzymes, so norethisterone exposure may increase or decrease unpredictably. Reduced exposure could compromise contraception.
How serious is the interaction between Norethisterone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough bleeding or adverse effects and add non-hormonal contraception if contraception is needed.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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