Drug interactions
Ocrelizumab + Rilonacept
Severity: Moderate
Ocrelizumab and Rilonacept: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 signaling, which modestly impairs host defense, while ocrelizumab depletes B cells. Together they may increase the risk of infections.
What this interaction means in plain words
Ocrelizumab and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ocrelizumab belongs to Central Nervous System; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression via IL-1 blockade and CD20 B-cell depletion.
What to do
Monitor for signs of infection and treat promptly. Screen for latent infections such as hepatitis B and tuberculosis before combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Rilonacept
Frequently asked questions
Can I take Ocrelizumab with Rilonacept?
MediHelp rates the interaction as moderate. Ocrelizumab and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks interleukin-1 signaling, which modestly impairs host defense, while ocrelizumab depletes B cells. Together they may increase the risk of infections.
How serious is the interaction between Ocrelizumab and Rilonacept?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and treat promptly. Screen for latent infections such as hepatitis B and tuberculosis before combined use.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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