Drug interactions
Ocrelizumab + Sirolimus
Severity: Moderate
Ocrelizumab and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair immune defence, so together they can increase the risk of serious and opportunistic infections. The risk is greater in transplant patients on multiple immunosuppressants.
What this interaction means in plain words
Ocrelizumab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ocrelizumab belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression from CD20 B-cell depletion and mTOR inhibition of T-cell proliferation.
What to do
Monitor closely for infections and consider antimicrobial prophylaxis according to transplant protocols. Review the need for ocrelizumab in patients on maintenance immunosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Ocrelizumab with Sirolimus?
MediHelp rates the interaction as moderate. Ocrelizumab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents impair immune defence, so together they can increase the risk of serious and opportunistic infections. The risk is greater in transplant patients on multiple immunosuppressants.
How serious is the interaction between Ocrelizumab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for infections and consider antimicrobial prophylaxis according to transplant protocols. Review the need for ocrelizumab in patients on maintenance immunosuppression.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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