Drug interactions
Ocrelizumab + Tacrolimus
Severity: Moderate
Ocrelizumab and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus suppresses T-cell function while ocrelizumab depletes B cells, so combined therapy raises the risk of serious and opportunistic infections. Patients may need closer surveillance than with either drug alone.
What this interaction means in plain words
Ocrelizumab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ocrelizumab belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression from calcineurin inhibition of T-cell activation and CD20-mediated B-cell depletion.
What to do
Monitor for infection and keep tacrolimus trough levels within the target range. Use prophylaxis per transplant protocol and reassess ocrelizumab need.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Ocrelizumab with Tacrolimus?
MediHelp rates the interaction as moderate. Ocrelizumab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus suppresses T-cell function while ocrelizumab depletes B cells, so combined therapy raises the risk of serious and opportunistic infections. Patients may need closer surveillance than with either drug alone.
How serious is the interaction between Ocrelizumab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and keep tacrolimus trough levels within the target range. Use prophylaxis per transplant protocol and reassess ocrelizumab need.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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