Drug interactions
Ocrelizumab + Trastuzumab deruxtecan
Severity: Moderate
Ocrelizumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and ocrelizumab adds B-cell depletion, so combined use may increase the risk of serious infection. The combination is uncommon since the drugs treat different diseases.
What this interaction means in plain words
Ocrelizumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ocrelizumab belongs to Central Nervous System; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression from chemotherapy-induced myelosuppression and anti-CD20 B-cell depletion.
What to do
Monitor neutrophil counts and signs of infection. Consider delaying ocrelizumab doses during significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Ocrelizumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Ocrelizumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and ocrelizumab adds B-cell depletion, so combined use may increase the risk of serious infection. The combination is uncommon since the drugs treat different diseases.
How serious is the interaction between Ocrelizumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection. Consider delaying ocrelizumab doses during significant neutropenia.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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