Drug interactions
Oliceridine + Posaconazole
Severity: Major
Oliceridine and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise oliceridine concentrations, increasing the risk of respiratory depression and excess sedation. Stopping the inhibitor may reduce opioid effect and lead to withdrawal or poor analgesia.
What this interaction means in plain words
Oliceridine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces oliceridine clearance, increasing exposure.
What to do
Use lower or less frequent oliceridine doses and monitor closely for respiratory depression and sedation. Re-titrate if posaconazole is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Posaconazole?
MediHelp rates the interaction as major. Oliceridine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can raise oliceridine concentrations, increasing the risk of respiratory depression and excess sedation. Stopping the inhibitor may reduce opioid effect and lead to withdrawal or poor analgesia.
How serious is the interaction between Oliceridine and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower or less frequent oliceridine doses and monitor closely for respiratory depression and sedation. Re-titrate if posaconazole is discontinued.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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