Drug interactions
Oliceridine + Vilazodone
Severity: Moderate
Oliceridine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid and serotonin syndrome has been reported with opioids combined with serotonergic antidepressants. Vilazodone raises serotonin activity, so the combination may increase risk of agitation, tremor, hyperthermia and autonomic instability. Opioid-related sedation can also be additive.
What this interaction means in plain words
Oliceridine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, plus additive CNS depression.
What to do
Monitor for signs of serotonin syndrome, especially at initiation and after dose increases. Stop the serotonergic agents and provide supportive care if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Vilazodone?
MediHelp rates the interaction as moderate. Oliceridine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is an opioid and serotonin syndrome has been reported with opioids combined with serotonergic antidepressants. Vilazodone raises serotonin activity, so the combination may increase risk of agitation, tremor, hyperthermia and autonomic instability. Opioid-related sedation can also be additive.
How serious is the interaction between Oliceridine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially at initiation and after dose increases. Stop the serotonergic agents and provide supportive care if it occurs.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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