Drug interactions
Omaveloxolone + Ribociclib
Severity: Moderate
Omaveloxolone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may raise omaveloxolone concentrations through CYP3A4 inhibition, increasing adverse effects such as liver enzyme elevation and lipid changes.
What this interaction means in plain words
Omaveloxolone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4 metabolism of omaveloxolone.
What to do
Avoid if possible; otherwise reduce omaveloxolone to 100 mg daily and monitor liver enzymes and adverse effects, reducing further if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Ribociclib?
MediHelp rates the interaction as moderate. Omaveloxolone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may raise omaveloxolone concentrations through CYP3A4 inhibition, increasing adverse effects such as liver enzyme elevation and lipid changes.
How serious is the interaction between Omaveloxolone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce omaveloxolone to 100 mg daily and monitor liver enzymes and adverse effects, reducing further if needed.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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