Drug interactions
Omaveloxolone + Rosiglitazone
Severity: Moderate
Omaveloxolone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP2C8 and reduce exposure to sensitive substrates such as rosiglitazone. This could lessen glycemic control.
What this interaction means in plain words
Omaveloxolone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Rosiglitazone belongs to Endocrine.
Why it happens
Induction of CYP2C8-mediated rosiglitazone metabolism by omaveloxolone.
What to do
Monitor blood glucose and HbA1c after starting omaveloxolone. Increase the rosiglitazone dose within labeled limits if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Rosiglitazone?
MediHelp rates the interaction as moderate. Omaveloxolone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may induce CYP2C8 and reduce exposure to sensitive substrates such as rosiglitazone. This could lessen glycemic control.
How serious is the interaction between Omaveloxolone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting omaveloxolone. Increase the rosiglitazone dose within labeled limits if control worsens.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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