Drug interactions
Omaveloxolone + Sirolimus
Severity: Moderate
Omaveloxolone and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and lower sirolimus exposure. Reduced levels could compromise immunosuppression in transplant patients.
What this interaction means in plain words
Omaveloxolone and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 increases sirolimus metabolism.
What to do
Monitor sirolimus trough concentrations after starting or stopping omaveloxolone. Increase the sirolimus dose if levels fall below target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Sirolimus?
MediHelp rates the interaction as moderate. Omaveloxolone and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may induce CYP3A4 and lower sirolimus exposure. Reduced levels could compromise immunosuppression in transplant patients.
How serious is the interaction between Omaveloxolone and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations after starting or stopping omaveloxolone. Increase the sirolimus dose if levels fall below target.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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