Drug interactions
Omaveloxolone + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Omaveloxolone and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP enzymes and could lower velpatasvir and voxilaprevir exposure, risking reduced antiviral efficacy. The clinical significance is not well established.
What this interaction means in plain words
Omaveloxolone and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Omaveloxolone may induce metabolizing enzymes (including CYP2C8 and CYP3A4), lowering substrate exposure; the exact mechanism is incompletely characterized.
What to do
Monitor virologic response and confirm sustained virologic response after treatment. Consider alternatives if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Omaveloxolone and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may induce CYP enzymes and could lower velpatasvir and voxilaprevir exposure, risking reduced antiviral efficacy. The clinical significance is not well established.
How serious is the interaction between Omaveloxolone and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor virologic response and confirm sustained virologic response after treatment. Consider alternatives if efficacy is a concern.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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