Drug interactions
Omeprazole + Stiripentol
Severity: Moderate
Omeprazole and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and may raise omeprazole concentrations, and it has mixed effects on CYP3A4. Omeprazole exposure and adverse effects may increase.
What this interaction means in plain words
Omeprazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omeprazole belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 (and variably affects CYP3A4), reducing omeprazole clearance.
What to do
Monitor for omeprazole adverse effects and reduce the dose if they occur, especially at high doses or in long-term use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Omeprazole with Stiripentol?
MediHelp rates the interaction as moderate. Omeprazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19 and may raise omeprazole concentrations, and it has mixed effects on CYP3A4. Omeprazole exposure and adverse effects may increase.
How serious is the interaction between Omeprazole and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for omeprazole adverse effects and reduce the dose if they occur, especially at high doses or in long-term use.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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