Drug interactions
Ondansetron + Osilodrostat
Severity: Moderate
Ondansetron and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, as can ondansetron. Together they may increase the risk of torsades de pointes, especially with hypokalemia or hypomagnesemia, which can occur in Cushing's disease.
What this interaction means in plain words
Ondansetron and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Check ECG at baseline and during therapy and correct potassium and magnesium. Use the lowest effective ondansetron dose or an alternative antiemetic if QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Ondansetron with Osilodrostat?
MediHelp rates the interaction as moderate. Ondansetron and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, as can ondansetron. Together they may increase the risk of torsades de pointes, especially with hypokalemia or hypomagnesemia, which can occur in Cushing's disease.
How serious is the interaction between Ondansetron and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and during therapy and correct potassium and magnesium. Use the lowest effective ondansetron dose or an alternative antiemetic if QTc rises.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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