Drug interactions
Ondansetron + Osimertinib
Severity: Moderate
Ondansetron and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is associated with QTc prolongation, and ondansetron has a dose-related QT effect. Using them together may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Ondansetron and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and electrolytes periodically and correct abnormalities. Avoid high-dose intravenous ondansetron where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Ondansetron with Osimertinib?
MediHelp rates the interaction as moderate. Ondansetron and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib is associated with QTc prolongation, and ondansetron has a dose-related QT effect. Using them together may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Ondansetron and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct abnormalities. Avoid high-dose intravenous ondansetron where possible.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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