Drug interactions
Ondansetron + Solifenacin
Severity: Moderate
Ondansetron and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin has been associated with dose-related QT prolongation, and ondansetron has a similar effect. Combined use may add to the risk of arrhythmia, particularly in older patients or those with cardiac disease.
What this interaction means in plain words
Ondansetron and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of the QT interval through effects on cardiac repolarization.
What to do
Use the lowest effective doses and correct potassium and magnesium. Obtain an ECG in patients with congenital long QT or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ondansetron and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Solifenacin
Frequently asked questions
Can I take Ondansetron with Solifenacin?
MediHelp rates the interaction as moderate. Ondansetron and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin has been associated with dose-related QT prolongation, and ondansetron has a similar effect. Combined use may add to the risk of arrhythmia, particularly in older patients or those with cardiac disease.
How serious is the interaction between Ondansetron and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and correct potassium and magnesium. Obtain an ECG in patients with congenital long QT or other risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
