Drug interactions
Ondansetron + Tacrolimus
Severity: Moderate
Ondansetron and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may add to the risk of torsades de pointes. The risk is higher in patients with electrolyte disturbances, heart failure, bradycardia or congenital long QT syndrome.
What this interaction means in plain words
Ondansetron and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation through blockade of cardiac repolarizing potassium currents.
What to do
Obtain a baseline ECG and correct potassium and magnesium before and during co-use, particularly with intravenous ondansetron. Avoid in congenital long QT syndrome and use a non-QT-prolonging antiemetic if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Ondansetron with Tacrolimus?
MediHelp rates the interaction as moderate. Ondansetron and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may add to the risk of torsades de pointes. The risk is higher in patients with electrolyte disturbances, heart failure, bradycardia or congenital long QT syndrome.
How serious is the interaction between Ondansetron and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before and during co-use, particularly with intravenous ondansetron. Avoid in congenital long QT syndrome and use a non-QT-prolonging antiemetic if risk factors are present.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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