Drug interactions
Orphenadrin + Prochlorperazine
Severity: Moderate
Orphenadrin and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine is sedating with anticholinergic properties, and orphenadrine adds to both. This may lead to drowsiness, confusion, dry mouth, constipation and urinary retention.
What this interaction means in plain words
Orphenadrin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and anticholinergic effects.
What to do
Monitor for sedation and anticholinergic effects, especially in older patients. Reduce doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Orphenadrin with Prochlorperazine?
MediHelp rates the interaction as moderate. Orphenadrin and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine is sedating with anticholinergic properties, and orphenadrine adds to both. This may lead to drowsiness, confusion, dry mouth, constipation and urinary retention.
How serious is the interaction between Orphenadrin and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, especially in older patients. Reduce doses if impairment occurs.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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