Drug interactions
Orphenadrin + Propofol
Severity: Moderate
Orphenadrin and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has sedating central effects that add to the anesthetic and sedative action of propofol. This can deepen sedation, prolong recovery and increase the risk of hypotension or respiratory depression.
What this interaction means in plain words
Orphenadrin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Titrate propofol to effect and expect lower dose requirements in patients taking orphenadrine. Monitor sedation depth, respiration and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Propofol
Frequently asked questions
Can I take Orphenadrin with Propofol?
MediHelp rates the interaction as moderate. Orphenadrin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has sedating central effects that add to the anesthetic and sedative action of propofol. This can deepen sedation, prolong recovery and increase the risk of hypotension or respiratory depression.
How serious is the interaction between Orphenadrin and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and expect lower dose requirements in patients taking orphenadrine. Monitor sedation depth, respiration and blood pressure.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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