Drug interactions
Osilodrostat + Phenobarbitone
Severity: Moderate
Osilodrostat and Phenobarbitone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbitone is an enzyme inducer that may reduce osilodrostat exposure and weaken cortisol control. Loss of efficacy may allow hypercortisolism to recur.
What this interaction means in plain words
Osilodrostat and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Phenobarbitone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and CYP2B6 increases osilodrostat metabolism.
What to do
Monitor cortisol levels and clinical response and increase the osilodrostat dose if needed. Lower the dose when phenobarbitone is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Osilodrostat
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
Frequently asked questions
Can I take Osilodrostat with Phenobarbitone?
MediHelp rates the interaction as moderate. Osilodrostat and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbitone is an enzyme inducer that may reduce osilodrostat exposure and weaken cortisol control. Loss of efficacy may allow hypercortisolism to recur.
How serious is the interaction between Osilodrostat and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels and clinical response and increase the osilodrostat dose if needed. Lower the dose when phenobarbitone is withdrawn.
What other medicines interact with Osilodrostat?
MediHelp also lists interactions of Osilodrostat with, for example, Amiodarone, Amisulpride, Chlorpromazine. The full list is on the Osilodrostat page.
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