Drug interactions
Osilodrostat + Ranolazine
Severity: Moderate
Osilodrostat and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval. Combined use may increase the risk of QT-related ventricular arrhythmias including torsades de pointes, especially with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Osilodrostat and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and repeat after starting or changing doses. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Ranolazine?
MediHelp rates the interaction as moderate. Osilodrostat and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval. Combined use may increase the risk of QT-related ventricular arrhythmias including torsades de pointes, especially with electrolyte abnormalities or heart disease.
How serious is the interaction between Osilodrostat and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after starting or changing doses. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs where possible.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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