Drug interactions
Osilodrostat + Risperidone
Severity: Major
Osilodrostat and Risperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia including torsades de pointes. Osilodrostat also causes hypokalemia, which adds to the risk.
What this interaction means in plain words
Osilodrostat and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osilodrostat belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, worsened by osilodrostat-related hypokalemia.
What to do
Obtain a baseline ECG and repeat after starting or changing doses, and correct potassium and magnesium before and during therapy. Consider an alternative antipsychotic if the QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Risperidone?
MediHelp rates the interaction as major. Osilodrostat and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia including torsades de pointes. Osilodrostat also causes hypokalemia, which adds to the risk.
How serious is the interaction between Osilodrostat and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after starting or changing doses, and correct potassium and magnesium before and during therapy. Consider an alternative antipsychotic if the QTc becomes prolonged.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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