Drug interactions
Osimertinib + Trimipramine
Severity: Moderate
Osimertinib and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or heart disease.
What this interaction means in plain words
Osimertinib and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and periodic ECGs, and correct potassium and magnesium abnormalities. Reduce the dose or change therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Trimipramine?
MediHelp rates the interaction as moderate. Osimertinib and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or heart disease.
How serious is the interaction between Osimertinib and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and periodic ECGs, and correct potassium and magnesium abnormalities. Reduce the dose or change therapy if QTc becomes markedly prolonged.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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