Drug interactions
Oxaliplatin + Palbociclib
Severity: Moderate
Oxaliplatin and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib commonly causes neutropenia, and oxaliplatin is myelosuppressive, so combined use may deepen neutropenia and raise infection risk.
What this interaction means in plain words
Oxaliplatin and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Additive myelosuppression from CDK4/6 inhibition and cytotoxic chemotherapy.
What to do
Monitor complete blood counts closely and interrupt or reduce palbociclib for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Oxaliplatin with Palbociclib?
MediHelp rates the interaction as moderate. Oxaliplatin and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib commonly causes neutropenia, and oxaliplatin is myelosuppressive, so combined use may deepen neutropenia and raise infection risk.
How serious is the interaction between Oxaliplatin and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and interrupt or reduce palbociclib for significant neutropenia.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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