Drug interactions
Oxaliplatin + Paromomycin
Severity: Minor
Oxaliplatin and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so systemic nephrotoxicity or ototoxicity is unlikely in most patients. Risk rises mainly with renal impairment or damaged intestinal mucosa.
What this interaction means in plain words
Oxaliplatin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxaliplatin belongs to Oncology; Paromomycin belongs to Anti Bacterial.
Why it happens
Theoretical additive nephro- and ototoxicity if paromomycin is systemically absorbed.
What to do
Monitor renal function in patients with kidney impairment or severe mucositis. No routine change is needed otherwise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Oxaliplatin with Paromomycin?
MediHelp rates the interaction as minor. Oxaliplatin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so systemic nephrotoxicity or ototoxicity is unlikely in most patients. Risk rises mainly with renal impairment or damaged intestinal mucosa.
How serious is the interaction between Oxaliplatin and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients with kidney impairment or severe mucositis. No routine change is needed otherwise.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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