Drug interactions
Oxaliplatin + Risperidone
Severity: Moderate
Oxaliplatin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and electrolyte disturbances, and risperidone also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmias, particularly with hypokalemia or hypomagnesemia from chemotherapy and vomiting.
What this interaction means in plain words
Oxaliplatin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, aggravated by oxaliplatin-related electrolyte disturbances.
What to do
Check ECG at baseline and during treatment, and keep potassium and magnesium within normal range. Review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Risperidone?
MediHelp rates the interaction as moderate. Oxaliplatin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and electrolyte disturbances, and risperidone also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmias, particularly with hypokalemia or hypomagnesemia from chemotherapy and vomiting.
How serious is the interaction between Oxaliplatin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and during treatment, and keep potassium and magnesium within normal range. Review other QT-prolonging drugs.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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