Drug interactions
Oxaliplatin + Sevoflurane
Severity: Moderate
Oxaliplatin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and oxaliplatin-induced electrolyte losses can worsen this. Perioperative arrhythmia risk may be increased in patients receiving oxaliplatin.
What this interaction means in plain words
Oxaliplatin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible contribution from oxaliplatin-related hypokalemia and hypomagnesemia.
What to do
Check baseline ECG, potassium, magnesium and calcium before anesthesia and correct any abnormalities. Monitor the ECG intraoperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Sevoflurane?
MediHelp rates the interaction as moderate. Oxaliplatin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and oxaliplatin-induced electrolyte losses can worsen this. Perioperative arrhythmia risk may be increased in patients receiving oxaliplatin.
How serious is the interaction between Oxaliplatin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium, magnesium and calcium before anesthesia and correct any abnormalities. Monitor the ECG intraoperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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