Drug interactions
Oxaliplatin + Trazodone
Severity: Moderate
Oxaliplatin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT prolongation. Oxaliplatin-related electrolyte loss from vomiting or diarrhea can further raise arrhythmia risk when trazodone is used.
What this interaction means in plain words
Oxaliplatin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, worsened by chemotherapy-induced electrolyte disturbances.
What to do
Monitor ECG and keep potassium and magnesium within normal range during oxaliplatin treatment. Consider an alternative antidepressant if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Trazodone?
MediHelp rates the interaction as moderate. Oxaliplatin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT prolongation. Oxaliplatin-related electrolyte loss from vomiting or diarrhea can further raise arrhythmia risk when trazodone is used.
How serious is the interaction between Oxaliplatin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range during oxaliplatin treatment. Consider an alternative antidepressant if QTc lengthens significantly.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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