Drug interactions
Oxaliplatin + Triclabendazole
Severity: Moderate
Oxaliplatin and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole has been associated with QT prolongation and oxaliplatin may also prolong the QT interval. Together they may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Oxaliplatin and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Because triclabendazole is given as a short course, consider deferring it until after oxaliplatin treatment if clinically feasible. Otherwise check ECG and electrolytes before and during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Oxaliplatin with Triclabendazole?
MediHelp rates the interaction as moderate. Oxaliplatin and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole has been associated with QT prolongation and oxaliplatin may also prolong the QT interval. Together they may increase the risk of ventricular arrhythmias.
How serious is the interaction between Oxaliplatin and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Because triclabendazole is given as a short course, consider deferring it until after oxaliplatin treatment if clinically feasible. Otherwise check ECG and electrolytes before and during treatment.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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