Drug interactions
Oxaliplatin + Vedolizumab
Severity: Moderate
Oxaliplatin and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin can cause myelosuppression, and vedolizumab alters gut immune surveillance. Used together they may modestly increase the risk of infection.
What this interaction means in plain words
Oxaliplatin and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression through chemotherapy-related myelosuppression and alpha4beta7 integrin inhibition.
What to do
Monitor neutrophil counts and clinical signs of infection during oxaliplatin cycles. Manage neutropenia per oncology protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Vedolizumab?
MediHelp rates the interaction as moderate. Oxaliplatin and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin can cause myelosuppression, and vedolizumab alters gut immune surveillance. Used together they may modestly increase the risk of infection.
How serious is the interaction between Oxaliplatin and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and clinical signs of infection during oxaliplatin cycles. Manage neutropenia per oncology protocols.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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