Drug interactions
Oxycodone + Perphenazine
Severity: Moderate
Oxycodone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine adds sedation and hypotension to oxycodone's CNS depression. As a CYP2D6 inhibitor, it may reduce conversion of oxycodone to oxymorphone, though this is of uncertain clinical effect, and it may shift oxycodone toward CYP3A4 metabolism.
What this interaction means in plain words
Oxycodone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus CYP2D6 inhibition by perphenazine altering oxycodone metabolism.
What to do
Monitor for sedation, respiratory depression and changes in analgesic effect, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Oxycodone with Perphenazine?
MediHelp rates the interaction as moderate. Oxycodone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine adds sedation and hypotension to oxycodone's CNS depression. As a CYP2D6 inhibitor, it may reduce conversion of oxycodone to oxymorphone, though this is of uncertain clinical effect, and it may shift oxycodone toward CYP3A4 metabolism.
How serious is the interaction between Oxycodone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and changes in analgesic effect, and use the lowest effective doses.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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