Drug interactions
Oxycodone + Selinexor
Severity: Moderate
Oxycodone and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, fatigue, and confusion, which may add to opioid-related sedation and cognitive impairment. This is a pharmacodynamic overlap rather than a pharmacokinetic interaction.
What this interaction means in plain words
Oxycodone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive CNS adverse effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion, and sedation, and counsel on fall and driving risk. Use the lowest effective oxycodone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Oxycodone with Selinexor?
MediHelp rates the interaction as moderate. Oxycodone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, fatigue, and confusion, which may add to opioid-related sedation and cognitive impairment. This is a pharmacodynamic overlap rather than a pharmacokinetic interaction.
How serious is the interaction between Oxycodone and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion, and sedation, and counsel on fall and driving risk. Use the lowest effective oxycodone dose.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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