Drug interactions
Oxymorphone + Propofol
Severity: Major
Oxymorphone and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol and opioids together produce profound additive sedation, respiratory depression and hypotension. This is useful in anesthesia but hazardous without airway and ventilatory support.
What this interaction means in plain words
Oxymorphone and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxymorphone belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression via opioid receptor and GABA-A mediated effects.
What to do
Use only where continuous monitoring of oxygenation, ventilation and blood pressure and airway management are available. Reduce propofol and opioid doses and titrate to effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Oxymorphone with Propofol?
MediHelp rates the interaction as major. Oxymorphone and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propofol and opioids together produce profound additive sedation, respiratory depression and hypotension. This is useful in anesthesia but hazardous without airway and ventilatory support.
How serious is the interaction between Oxymorphone and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where continuous monitoring of oxygenation, ventilation and blood pressure and airway management are available. Reduce propofol and opioid doses and titrate to effect.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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