Drug interactions
Oxytetracycline + Sucralfate
Severity: Moderate
Oxytetracycline and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate can markedly reduce absorption of oral oxytetracycline, risking subtherapeutic antibiotic concentrations and treatment failure.
What this interaction means in plain words
Oxytetracycline and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxytetracycline belongs to Anti Bacterial; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Chelation of the tetracycline by aluminum in sucralfate in the gastrointestinal tract.
What to do
Give oxytetracycline at least 2 hours before sucralfate, or choose an alternative acid-suppression approach. Monitor for clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Other interactions of Oxytetracycline
- Isotretinoin + Oxytetracycline Contraindicated
- Aluminum hydroxide + Oxytetracycline Moderate
- Ampicillin-sulbactam + Oxytetracycline Moderate
- Ampicillin + Oxytetracycline Moderate
- Atracurium + Oxytetracycline Moderate
- Bismuth subsalicylate + Oxytetracycline Moderate
Frequently asked questions
Can I take Oxytetracycline with Sucralfate?
MediHelp rates the interaction as moderate. Oxytetracycline and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate can markedly reduce absorption of oral oxytetracycline, risking subtherapeutic antibiotic concentrations and treatment failure.
How serious is the interaction between Oxytetracycline and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oxytetracycline at least 2 hours before sucralfate, or choose an alternative acid-suppression approach. Monitor for clinical response.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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