Drug interactions
Ozanimod + Paliperidone
Severity: Moderate
Ozanimod and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and paliperidone prolongs the QT interval. Together they may increase the risk of arrhythmia, so the label advises against starting ozanimod in patients taking QT-prolonging drugs without cardiology input.
What this interaction means in plain words
Ozanimod and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive effects of S1P-receptor-mediated bradycardia and QT prolongation.
What to do
Obtain an ECG before starting ozanimod and seek cardiology advice if on paliperidone. Monitor heart rate and QT and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Paliperidone?
MediHelp rates the interaction as moderate. Ozanimod and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and paliperidone prolongs the QT interval. Together they may increase the risk of arrhythmia, so the label advises against starting ozanimod in patients taking QT-prolonging drugs without cardiology input.
How serious is the interaction between Ozanimod and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and seek cardiology advice if on paliperidone. Monitor heart rate and QT and correct electrolytes.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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