Drug interactions
Ozanimod + Pentazocine
Severity: Moderate
Ozanimod and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, so drugs that raise adrenergic or serotonergic activity may cause hypertensive or serotonergic reactions. Pentazocine can raise blood pressure and heart rate, and the clinical risk is largely theoretical.
What this interaction means in plain words
Ozanimod and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Possible MAO inhibition by ozanimod metabolites combined with sympathomimetic and mild serotonergic effects of pentazocine.
What to do
Monitor blood pressure and for serotonergic symptoms; prefer another analgesic if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Pentazocine?
MediHelp rates the interaction as moderate. Ozanimod and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolites inhibit MAO-B in vitro, so drugs that raise adrenergic or serotonergic activity may cause hypertensive or serotonergic reactions. Pentazocine can raise blood pressure and heart rate, and the clinical risk is largely theoretical.
How serious is the interaction between Ozanimod and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for serotonergic symptoms; prefer another analgesic if hypertension occurs.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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