Drug interactions
Ozanimod + Ribociclib
Severity: Moderate
Ozanimod and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect cardiac conduction, with ribociclib prolonging QT and ozanimod slowing heart rate. Combined use may raise arrhythmia risk, particularly torsades de pointes.
What this interaction means in plain words
Ozanimod and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on QT interval and heart rate.
What to do
Obtain a baseline ECG before starting ozanimod and monitor ECG and electrolytes. Seek cardiology advice for patients with existing QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Ribociclib?
MediHelp rates the interaction as moderate. Ozanimod and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can affect cardiac conduction, with ribociclib prolonging QT and ozanimod slowing heart rate. Combined use may raise arrhythmia risk, particularly torsades de pointes.
How serious is the interaction between Ozanimod and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ozanimod and monitor ECG and electrolytes. Seek cardiology advice for patients with existing QT risk.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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