Drug interactions
Ozanimod + Sirolimus
Severity: Moderate
Ozanimod and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod lowers circulating lymphocytes and sirolimus is immunosuppressive, so combined use may increase the risk of infection. The effect of ozanimod on lymphocyte counts can persist after stopping.
What this interaction means in plain words
Ozanimod and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression through lymphocyte sequestration and mTOR inhibition.
What to do
Monitor for infections and check lymphocyte counts periodically. Consider the persistence of ozanimod effects when changing therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Sirolimus?
MediHelp rates the interaction as moderate. Ozanimod and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod lowers circulating lymphocytes and sirolimus is immunosuppressive, so combined use may increase the risk of infection. The effect of ozanimod on lymphocyte counts can persist after stopping.
How serious is the interaction between Ozanimod and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections and check lymphocyte counts periodically. Consider the persistence of ozanimod effects when changing therapies.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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