Drug interactions
Ozanimod + Solifenacin
Severity: Moderate
Ozanimod and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and affect conduction, and solifenacin can prolong the QT interval. Bradycardia increases the risk of torsades de pointes with QT-prolonging drugs.
What this interaction means in plain words
Ozanimod and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effects of ozanimod-induced bradycardia and solifenacin QT prolongation.
What to do
Obtain an ECG before starting ozanimod and consider cardiology advice. Monitor heart rate and QTc during initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Solifenacin?
MediHelp rates the interaction as moderate. Ozanimod and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and affect conduction, and solifenacin can prolong the QT interval. Bradycardia increases the risk of torsades de pointes with QT-prolonging drugs.
How serious is the interaction between Ozanimod and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and consider cardiology advice. Monitor heart rate and QTc during initiation.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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