Drug interactions
Ozanimod + Tacrolimus
Severity: Moderate
Ozanimod and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod slows heart rate and conduction and tacrolimus can prolong the QT interval, raising arrhythmia concern. Both are also immunosuppressive, so infection risk may be additive.
What this interaction means in plain words
Ozanimod and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive bradycardic/QT effects and additive immunosuppression via lymphocyte sequestration and calcineurin inhibition.
What to do
Perform an ECG before starting ozanimod and monitor for bradycardia and infection. Seek cardiology advice if the patient has significant QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Tacrolimus?
MediHelp rates the interaction as moderate. Ozanimod and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod slows heart rate and conduction and tacrolimus can prolong the QT interval, raising arrhythmia concern. Both are also immunosuppressive, so infection risk may be additive.
How serious is the interaction between Ozanimod and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform an ECG before starting ozanimod and monitor for bradycardia and infection. Seek cardiology advice if the patient has significant QT risk factors.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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