Drug interactions
Ozanimod + Voriconazole
Severity: Moderate
Ozanimod and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and voriconazole prolongs the QT interval, so bradycardia may increase the risk of torsades de pointes. Ozanimod initiation is generally avoided in patients on QT-prolonging drugs.
What this interaction means in plain words
Ozanimod and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Additive effects of QT prolongation and ozanimod-induced bradycardia.
What to do
Obtain an ECG before starting ozanimod and seek cardiology advice if on voriconazole; monitor heart rate and QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Voriconazole?
MediHelp rates the interaction as moderate. Ozanimod and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and voriconazole prolongs the QT interval, so bradycardia may increase the risk of torsades de pointes. Ozanimod initiation is generally avoided in patients on QT-prolonging drugs.
How serious is the interaction between Ozanimod and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and seek cardiology advice if on voriconazole; monitor heart rate and QTc.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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