Drug interactions
Ozanimod + Zolmitriptan
Severity: Moderate
Ozanimod and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and zolmitriptan has vasoconstrictive and serotonergic effects. The labeling for ozanimod warns of hypertensive reactions with drugs affecting norepinephrine or serotonin. Zolmitriptan is metabolized by MAO-A, so the interaction is mainly theoretical.
What this interaction means in plain words
Ozanimod and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by an ozanimod metabolite adds to the monoaminergic and pressor effects of the triptan.
What to do
Monitor blood pressure when used together and counsel patients to report severe headache or palpitations. Consider a non-serotonergic alternative if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Zolmitriptan?
MediHelp rates the interaction as moderate. Ozanimod and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and zolmitriptan has vasoconstrictive and serotonergic effects. The labeling for ozanimod warns of hypertensive reactions with drugs affecting norepinephrine or serotonin. Zolmitriptan is metabolized by MAO-A, so the interaction is mainly theoretical.
How serious is the interaction between Ozanimod and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when used together and counsel patients to report severe headache or palpitations. Consider a non-serotonergic alternative if hypertension occurs.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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