Drug interactions
Paclitaxel + Posaconazole
Severity: Moderate
Paclitaxel and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is cleared via CYP2C8 and CYP3A4, so posaconazole may raise exposure to some degree. This may increase neutropenia and neuropathy, though the magnitude is uncertain.
What this interaction means in plain words
Paclitaxel and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 reduces a secondary metabolic pathway of paclitaxel (and possibly P-gp efflux).
What to do
Monitor blood counts and neuropathy, and reduce paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Posaconazole?
MediHelp rates the interaction as moderate. Paclitaxel and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is cleared via CYP2C8 and CYP3A4, so posaconazole may raise exposure to some degree. This may increase neutropenia and neuropathy, though the magnitude is uncertain.
How serious is the interaction between Paclitaxel and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and reduce paclitaxel dose if toxicity develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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